How Berberine Radically Changes Your Metabolism

 If you are carb-sensitive, you may wish there was a “magic pill” that you could take that would make weight loss easier. Even better, this pill would mimic the effects of low-calorie dieting and exercise, while staving off metabolic diseases, cancer, and diabetes.

Incredibly, such a remedy exists… and has existed for hundreds of years!

Whether you just want to lose weight or if you have ongoing health conditions that limit your vitality, it can help to know of the benefits of an amazing herbal supplement used for over 1000 years in the Far East with great success. This supplement is natural and safe and can help combat insulin sensitivity and many other health risk factors, as science has now proven.

This natural herbal remedy is berberine.

What is it? Berberine is a yellow-colored plant extract (technically, an alkaloid) with several research-proven benefits to human metabolism. The berberine we sell is derived from plant bark. Used for hundreds of years in Ayurvedic and Chinese Medicine,[i] berberine acts as a natural antibiotic and anti-inflammatory, that also has anticancer[ii] and anti-diabetic effects. Safe and cost-effective,[iii] it can also help lower blood sugar and cholesterol[iv] and make weight loss easier.

Berberine can also be extracted from a number of different medicinal herbs, including goldenseal, barberry and Oregon grape root. Although quite bitter, when taken in capsule form you get all the benefits without the unpleasant taste.

 How does it work? Berberine helps to burn fat, lower cholesterol and blood sugar, increases your ability to fight illness and stress, and can even delay aging.[v] It activates the same biochemical pathways that are triggered by fasting (caloric restriction) and working out. Here’s more on how it enhances health.

Berberine triggers AMPK: Research has shown that berberine activates a special enzyme known as AMPK, which promotes longevity and reduces fat storage. The AMPK mechanism helps the body fight obesity and diabetes,[vi] and enhances fatty acid oxidation and decreases glucose production in the liver.

AMPK helps regulate energy metabolism, stress resistance, cellular health, and ultimately the aging process. AMPK activation is enhanced by exercise, caloric restriction, medication such as the drug Metformin, and botanical extracts such as berberine.[vii]

The AMPK system may be partly responsible for the health benefits of exercise[viii] and AMPK is considered an exercise mimetic. Amazingly, research on mice has shown that a certain AMPK pathway can be targeted by orally active pills to enhance running endurance by 44%, even in sedentary subjects.[ix]

AMPK also helps mimic the effects a low-calorie diet. Lower calorie diets help fight aging; long-term caloric restriction without malnutrition has been shown to reduce age-related and all-cause mortality in primates.[x]

Further, AMPK activates certain short-term and long-term ATP-producing catabolic pathways (such as fatty acid oxidation and glycolysis) and switches off ATP-consuming anabolic pathways (such as lipogenesis, or “fat building”).[xi] In other words, it helps the body shift from energy storage to energy expenditure, which is great if your goal is to lose weight.

AMPK helps stimulate the effects of leptin (the “satiety hormone” that inhibits hunger) and adiponectin (which helps regulate glucose levels and fatty acid breakdown). In this way, AMPK helps regulate appetite, food intake and energy expenditure at the whole body level.[xii]

Thus through AMPK activation, berberine helps you mediate appetite, burn fat and lose weight!

The biochemical background: AMPK stands for AMP-activated protein kinase, and it plays an important role in the regular “cleaning up” of your cells. Cellular death, clearing and regeneration is a normal part of life. Known to biochemists as the process of autophagy, this is an essential physiological process that allows the orderly degradation and recycling of cellular components.

Experiments in mammals have shown that AMPK controls autophagy (this cellular “recycling”) through several complex signaling pathways, such as mTOR (explained in detail below), all of which enhances the quality of cellular housekeeping.

A loss of sensitivity of AMPK activation impairs metabolic regulation, and increases stress at the cellular level (via increased oxidative stress and reduced autophagic clearance). [xiii] Because of these properties, AMPK is at the forefront of much new research into longevity and disease prevention.

Berberine inhibits mTOR signaling: Berberine is able to inhibit the mTOR signaling pathway, which may decrease your risk of developing common diseases, such as cancer, type 2 diabetes, and obesity.

The biochemical background: The mTOR cascade (which, for any total biochem techies out there, stands for mammalian or mechanistic target of rapamycin) is an important and complex signaling pathway in the human body.

A biochemical signaling pathway is a series of chemical reactions that occur between cells. These “signals” serve as messages that tell cells what to do: what functions to increase or decrease at the cellular level. Essentially, signaling pathways govern how our bodies operate and age. Being able to regulate signaling pathways is therefore one way to change cellular functions. There are many types of signaling pathways continuously at work in the human body.

The mTOR signaling pathway is a process that is important to the regulation of a cell’s cycle (the cell’s “lifespan”), and therefore to organismal growth and metabolic balance (homeostasis). The mTOR pathway regulates many major cellular processes. Indeed, mTOR deregulation has been associated with an increasing number of disease conditions, such as cancer, obesity, type 2 diabetes, and neurodegeneration (a category of neuron-related pathologies that includes Alzheimer’s and Parkinson’s).[xiv]

Thus many common pathological conditions, including cancer and neurodegeneration, might benefit from mTOR inhibition[xv], although research on this topic is ongoing. Through the actions of AMPK, Berberine helps inhibit the mTOR signaling pathway.

What else does Berberine do?

Berberine affects the body at the molecular level and has many proven pharmacological benefits, including lowering blood glucose and lipids.[xvi] Recent studies have also suggested it may be able to kill cancer cells[xvii] and block their proliferation,[xviii] and have a possible potential role in the treatment and prevention of osteoporosis (porous bones).[xix] Here are more conditions that berberine may improve.

Obesity: Berberine has been shown to correlate with reduced body mass index and waist circumference in study subjects.[xx] Researchers have concluded that it has a moderate weight loss effect[xxi] and may have potential in treating the metabolic mechanisms that contribute to obesity.[xxii]

Type 2 diabetes: Berberine helps regulate blood sugar in type 2 diabetes patients as well as Metformin does (Metformin is a common brand of the drug glucophage).[xxiii] Berberine reduces the amount of glucose produced in the liver, and improves insulin sensitivity, which in turn reduces insulin-production burden on the pancreas. Research shows it is a potent oral hypoglycemic agent. [xxiv]

Insulin resistance: Conditions that typically correspond with insulin resistance include type 2 diabetes, high cholesterol, high blood pressure, and polycystic ovarian syndrome. Insulin resistance can make weight loss very challenging. However, because berberine improves insulin sensitivity, it can help reverse this effect and enhance weight loss in people with these chronic conditions.[xxv]

Hyperlipidemia: Too much “bad” cholesterol and triglycerides (a type of fat) in your blood is associated with an increased risk of heart disease and stroke. Berberine has been shown to have a therapeutic effect on hyperlipidemia,[xxvi] reducing these risk.

 How should I take it? Have one capsule in the morning, unless you eat carbohydrates after 3pm. If the latter, then have one capsule at night or with the carbs. Berberine capsules are now available in the Julian Bakery online store.

Note: if you are diabetic, consult with your doctor before taking berberine about how this herbal extract might help you lower your needs for conventional medications. Many diabetics can safely take berberine, but we recommend you do so under a doctor’s supervision.

Written By: Heath Squier / CEO / Julian Bakery. Inc.






























    Hi Heath! Very informative article. You have documented every point very well; obviously you studied this thoroughly. I am very interested in this product. Thank you!

  2. Gina Penner

    How do I order this? Very interested in using this product.

Comments are closed.


  • Now Available! Incredibly Soft & Delicious Julian Bakery® Keto Thin®  Cookies | 3 Net Carbs | 3 Carbs Not From Fiber | 1g Sugar | #MonkFruit Sweetened |USDA #Organic | #GlutenFree | Grain-Free | Rich Delicious Taste | 19g Fat | 10g #Protein | #Vegan | #Paleo | #Keto | Free Shipping | Available on @amazon | by @julianbakery | Incredible #Chocolate Taste | Save 10% Off + Free Shipping | Use Promo Code FB10
  • Make #Keto easy with our new delicious | Julian Bakery® Keto Thin® Bread. This incredible 1 Carb per slice bread uses #organic ingredients and has 0 Net Carbs per slice. Soft amazing bread that can be eaten with or without roasting. This keto bread is a true game changer. It’s #glutenfree #grainfree #lowcarb #keto #gmofree | Grab some today with free shipping & 10% off with promo code FB10 @julianbakery #weightloss
  • We have @amazon Prime and our site stocked up with our delicious #glutenfree #grainfree #keto thin Pizza 🍕 Crust Mix! Simply add water roll out.This awesome #vegetarian & #Paleo crust is delicious! Get FREE shipping on and @Amazon provides the ideal carb refeed day for #crossfit special  #bodybuilding #p90x #lowcarb #weightloss #weightlossjourney #weightlosstransformation @julianbakery
  • The perfect #keto cookie 🍪 with 12g Fat from C8 Oil & #organic peanut butter combined with 12g #egg white #protein this delicious chocolate chip filled #glutenfree and grain free cookie is simply amazing. Grab this @julianbakery ProCookie from our online store today with free shipping and 10% off using promo code FB10 @julianbakery
  • Make #Keto easy with our new delicious | Julian Bakery® Keto Thin® Bread. This incredible 1 Carb per slice bread uses #organic ingredients and has 0 Net Carbs per slice. Soft amazing bread that can be eaten with or without toasting. This keto bread is a true game changer. It’s #glutenfree #grainfree #lowcarb #soyfree #gmofree | special thanks to @helens_keto_journey for this pic | Grab some today with free shipping & 10% off with promo code FB10 | #sugarfree Jam | Grab our #ketobread today at @julianbakery #weightloss
  • Julian Bakery® Paleo Thin® Vanilla Cake #protein bars are delicious. This amazing #proteinbar is #glutenfree and packed with 20g of protein, 1g sugar (No Added Sugar) #keto friendly and ideal for building lean defined muscle. Grab some today with free shipping nationwide on @Amazon or @julianbakery today!
  • Boom! Organic Blackberries + Almond butter and our #Almond #Paleo Bread which has 7g protein per slice with 60cal 5g fiber and 6g carbs with (1 net carb). Our #julianbakery #paleobreads are #lowcarb #lchf #keto #glutenfree #grainfree #gmofree and best of a delicious! This delicious picture is our Almond #paleobread . Avail in almond, coconut, cinn raisin, and honey! Buy this and 100's of other items like #paleobars #paleoprotein #paleobread #coconutwraps #paleocrackers #paleocereal #paleochocolate and more (buy 6+ items for FREE shipping nationwide) Goto: @julianbakery #paleo #paleodiet special thanks to @hungryhappywhole for this shot #bodybuilding #crossfit #abs #sixpack #instafit #fitmeals #foodporn #fitspo #eggporn #foodporn #paleodiet #diet #weightloss @julianbakery "We Make Paleo Easy!" Now Avail In Our Online Store!! Sold in @wholefoods nationwide and 10,000 other stores use our store locator on our site at @julianbakery
  • Now Available! Incredibly Soft & Delicious Julian Bakery® Keto Thin®  Brownies | 196 Calories | 3 Net Carbs | 3 Carbs Not From Fiber | 1g Sugar | #MonkFruit Sweetened |USDA #Organic | #GlutenFree | Grain-Free | Rich Delicious Taste | 16g Fat | 10g #Protein | #Vegan | #Paleo | #Keto | Free Shipping | Available on @amazon | by @julianbakery | Incredible #Chocolate Taste | Save 10% Off + Free Shipping | Use Promo Code FB10
  • Curb your appetite with our delicious @julianbakery Paleo #Bread 🍞 options. Available in our new #paleobread seed medley & sandwich variety / Avail @amazon @julianbakery and our #coconut and #almond #paleo bread avail @wholefoods and with free shipping nationwide. Our #glutenfree and #lowcarb breads are also #keto and #grainfree and packed with 7g of egg 🥚 white #protein per slice 5g fiber making it ideal for #bodybuilding or any #fitness or #weightloss or #diet program. They range from 35 calories to 70 Calories (depending on the variety) helping you along in your #weightlossjourney and helping for an awesome #weightlosstransformation (special thanks to the @lisamcleod for this picture) no matter if your #paleo or #vegetarian or looking for a bread that promotes optimal health that uses #organic ingredients then our @julianbakery Paleo Bread is for you. #toast our bread in high for optimal results. Shown with #organic #avocado 🥑 and #egg Visit by @julianbakery (Free Shipping Nationwide) #julianbakery @julianbakery
  • Our delicious #lowcarb breads are all glutenfree, grain free, and #keto | Our breads make for unlimited meal possibilities. Special thanks to @ravenous.eats for this shot! Save 10% off + free 2 day shipping with promo code FB10 @julianbakery
  • Love #peanutbutter ? We got you covered with our delicious #proteinbar and #protein #organic #cookie and #granola options that are all #lowcarb #glutenfree #grainfree and #gmofree. Available @amazon or @julianbakery with free shipping nationwide. Save 10% off using promo code: FB10
  • Finally a way to get that crunch without so many carbs! At Julian Bakery we make foods that keep you on track. Grab our delicious variety pack of USDA #organic Primal Thin® or #Paleo Thin® #lowcarb #glutenfree Crackers! These delicious #crackers put the crunch back into you #diet without setting you back! Designed with ingredients that support optimal health and provide ideal Organic fuel for your #weightlosstransformation being #grainfree no matter what #bodybuilding plan your on or whatever kind of #fitness program like #crossfit or #cycling or #yoga or #pilates these #vegan (Paleo Thin Only)  and #vegetarian and #Paleo Diet compliant Crackers are ideal for you and on @Amazon Prime! Look for the new variety box pack!! Ideal frackers for your #weightlossjourney as they provide ideal macros for #weightloss when paired with the plan which is #protein + #vegetables + @instaketones #ketones #ketone . More info & Free Shipping : @julianbakery Save 10% Off + Get Free Shipping With Promo Code: FB10

Follow Us!